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home > Uitgaven > Jun '23. Peptide receptor radionuclide therapy (PRRT) for neuroendocrine tumours

Jun '23. Peptide receptor radionuclide therapy (PRRT) for neuroendocrine tumours

Auteur

T. Brabander, Q.G. de Lussanet de la Sabloniere, F.A. Verburg

Vakblad

TvNG

Editie

2023-02, juni

Thema

Radionuclidentherapie


 

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  • Inhoudsopgave

Neuroendocrine neoplasms are a rare type of tumour that typically have a slow growing pattern. Most neuroendocrine tumours express high levels of somatostatin receptors type 2 (SSTR-2) on their cell surface. These receptors are a potential target for radiolabelled somatostatin analogues. Since 2017, peptide receptor radionuclide therapy (PRRT) with [177Lu]Lu-DOTATATE is EMA and FDA approved for treatment of metastatic and/or advanced gastroenteropancreatic neuroendocrine tumours (GEPNETs).

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