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home > Uitgaven > Sept '25. Quantification of P-glycoprotein function using [18F]MC225 PET

Sept '25. Quantification of P-glycoprotein function using [18F]MC225 PET

Proefschrift

Auteur

G. Salvi de Souza

Vakblad

TvNG

Editie

2025-03, september


 

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  • Inhoudsopgave

P-glycoprotein (P-gp), a member of the ATP-binding cassette (ABC) transporter family, plays a vital role in drug distribution, barrier function, and disease mechanisms. It is highly expressed at biological interfaces such as the blood-brain barrier (BBB), gastrointestinal tract, liver and kidneys, where it actively effluxes xenobiotics and therapeutic agents, thereby affecting drug efficacy and resistance. Beyond drug delivery, P-gp is involved in neurodegenerative diseases, epilepsy and cancer resistance, making it a key target in clinical research.

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